Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

Abstract excerpt

, with prominent co-regulation of translation genes in severe malaria between host and parasite. Multivariate analyses suggested that increased expression of granulopoiesis and interferon-γ-related genes, together with inadequate suppression of type 1 interferon signaling, best explained severity of infection. These findings provide a framework for understanding the contributions of host and parasite to the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aquaculture disease management and microbiota
• Share to Malaria Research and Control
• Share to Mosquito-borne diseases and control