Article

Complement Activation Induces Excessive T Cell Cytotoxicity in Severe COVID-19

2021-06-14

Abstract excerpt

Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathogenesis, and it remains unclear if T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and proteomics with mechanistic studies assessing pathogenic T cell functions and inducing signals. We identified activated, CD16<sup>+</sup> T cells with increased cytotoxic functions in severe COVID-19...

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Literature Corpus work: b317951c-c7da-546b-8f00-8c373257e342
DOI: 10.2139/ssrn.3866835

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