Article

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

2021-06-11

Abstract excerpt

<h4>Summary</h4> Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathogenesis, and it remains unclear if T cells also contribute to disease pathology. Here, we combined single-cell transcriptomics and proteomics with mechanistic studies to assess pathogenic T cell functions and inducing signals. We identified highly activated, CD16 + T cells with increased cytotoxic functions...

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Literature Corpus work: 28d9f68f-87d5-59fb-9f89-10b34e005a6e
DOI: 10.1101/2021.06.08.21258481

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