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Article

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

28 Dec 2021

Abstract excerpt

Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with mechanistic studies to assess pathogenic T cell functions and inducing signals. We identified highly activated CD16 + T cells with increased cytotoxic functions in...

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PMID: 35032429
DOI: 10.1016/j.cell.2021.12.040

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