Article

Fibrotic Extracellular Matrix Preferentially Induces a Partial Epithelial-Mesenchymal Transition Phenotype in a 3-D Agent Based Model of Fibrosis

2024-06-22

Abstract excerpt

One of the main drivers of fibrotic diseases is epithelial-mesenchymal transition (EMT): a transdifferentiation process in which cells undergo a phenotypic change from an epithelial state to a pro-migratory state. The cytokine transforming growth factor- β 1 (TGF- β 1) has been previously shown to regulate EMT. TGF- β 1 binds to fibronectin (FN) fibrils, which are the primary extracellular matrix (ECM) componen...

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Literature Corpus work: b2f69a93-b8b8-5eee-b88e-67ed75d62905
DOI: 10.1101/2024.06.18.599477

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