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Article

Physical defects in basement membrane-mimicking collagen-IV matrices trigger cellular EMT and invasion.

Integrative biology : quantitative biosciences from nano to macro - 18 Jun 2018

Walter Christopher, Davis Joshua T, Mathur Jairaj, Pathak Amit

Abstract excerpt

In fibrosis and cancer, degradation of basement membrane (BM) and cell invasion are considered as key outcomes of a cellular transformation called epithelial-mesenchymal transition (EMT). Here, we pose a converse question - can preexisting physical defects in the BM matrix cause EMT in normal epithelial cells? On a BM-mimicking matrix of collagen-IV-coated polyacrylamide (PA) gel, we have discovered a reverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29790537
DOI: 10.1039/c8ib00034d

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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