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Fibrotic extracellular matrix preferentially induces a partial Epithelial-Mesenchymal Transition phenotype in a 3-D agent based model of fibrosis.

Mathematical biosciences - 1 Mar 2025

Kim Kristin P, Lemmon Christopher A

Abstract excerpt

One of the main drivers of fibrotic diseases is epithelial-mesenchymal transition (EMT): a transdifferentiation process in which cells undergo a phenotypic change from an epithelial state to a pro-migratory state. The cytokine transforming growth factor-β1 (TGF-β1) has been previously shown to regulate EMT. TGF-β1 binds to fibronectin (FN) fibrils, which are the primary extracellular matrix (ECM) component in...

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Epithelial Cells
Epithelial-Mesenchymal Transition
Extracellular Matrix
Fibronectins
Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Signal Transduction

Transforming Growth Factor beta1

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Identifiers

PMID: 39832653
DOI: 10.1016/j.mbs.2025.109375
PMCID: PMC11925401

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