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Article

An ancient retrotransposon provides species-specific tuning of IL-18 inflammatory signaling

2026-05-26

Abstract excerpt

Species differ markedly in how they regulate immune responses, yet the molecular basis of this variation remains incompletely understood. Here, we characterize an underexplored regulatory mechanism of the pro-inflammatory IL-18 pathway, centered on a truncated IL18R1 isoform with striking species-specific expression differences. This isoform, IL18R1-Short , derives from an ancient LINE2 retrotransposon insertion...

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Identifiers and source

Literature Corpus work
b2a4b500-3300-5957-90e4-8f1a60a93bbd
DOI
10.64898/2026.05.25.727421
Open publication

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An ancient retrotransposon provides species-specific tuning of IL-18 inflammatory signalingDOI 10.64898/2026.05.25.727421
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