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Article

Complement activation in the tubulointerstitium: AKI, CKD, and in between.

Kidney international - 1 Oct 2014

Brar Jyoti E, Quigg Richard J

Abstract excerpt

Complement activation is actively regulated to prevent injudicious activation, such as on peritubular endothelia and basolateral aspects of tubules. Miao et al. studied mice in which the key complement regulator, Crry, was deleted from tubular cells. This lacked functional consequence in unmanipulated animals. Yet, following ischemia-reperfusion, there was greater injury due to alternative pathway activation of...

Topics

Animals
Genetic Predisposition to Disease
Receptors, Complement
Reperfusion Injury

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25265946
DOI: 10.1038/ki.2014.168

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