Article

Nucleocytoplasmic transport senses mechanics independently of cell density in cell monolayers

2024-01-12

Abstract excerpt

Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes in health and disease. In single cells, mechanotransduction involves the transmission of force to the cell nucleus, where it affects nucleocytoplasmic transport (NCT) and the subsequent nuclear localization of transcriptional regulators such as YAP. However, if and how NCT is mechanosensitive in multicellular system...

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Literature Corpus work: 9b528926-3399-5465-8418-041e88c8c909
DOI: 10.1101/2024.01.11.575167

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