Article

Myeloid Cell States in Influenza-Associated Pulmonary Aspergillosis Are Shaped by Iron Overload and Metabolic Reprogramming

2026-04-25

Abstract excerpt

Virus-associated pulmonary aspergillosis is a life-threatening secondary infection that substantially increases morbidity and mortality in critically ill patients with respiratory virus infections. Influenza A virus (IAV) and SARS-CoV2 are known to disrupt pulmonary homeostasis, the mechanisms by which these perturbations render the host susceptibility to Aspergillus fumigatus (Af) remain incompletely understood....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b22066b0-b73d-55a6-a471-2289b9ff6bd3
DOI: 10.64898/2026.04.22.720189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myeloid Cell States in Influenza-Associated Pulmonary Aspergillosis Are Shaped by Iron Overload and Metabolic ReprogrammingDOI 10.64898/2026.04.22.720189Read

Broad remodeling of the pulmonary immune landscape occurs during IAPA with specific functional deficits of neutrophil subsetsSemantic proximity Read

Crucial role for iron metabolism in mediating influenza A virus infection and associated diseaseSemantic proximity Read

Computational modeling of macrophage iron sequestration during host defense against AspergillusSemantic proximity Read

Integrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infectionSemantic proximity Read

WTAP-mediated epitranscriptomic program in alveolar macrophages confers prolonged protection against postinfluenza bacterial pneumoniaSemantic proximity Read

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.Semantic proximity Read

Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary AspergillosisSemantic proximity Read

Post-Influenza Environment Reduces Aspergillus fumigatus Conidia Clearance and Facilitates Invasive Aspergillosis In VivoSemantic proximity Read

Spatiotemporal Analysis of Lung Immune Dynamics in Lethal Coccidioides posadasii InfectionSemantic proximity Read

Unveiling the intersection: ferroptosis in influenza virus infectionSemantic proximity Read

Genome-wide fitness profiling reveals adaptations required by Haemophilus in coinfection with influenza A virus in the murine lungSemantic proximity Read

Metabolic dysregulation induces impaired lymphocyte memory formation during severe SARS-CoV-2 infectionSemantic proximity Read