Article

Computational modeling of macrophage iron sequestration during host defense against <i>Aspergillus</i>

2022-01-27

Abstract excerpt

Iron is essential to the virulence of Aspergillus species, and restricting iron availability is a critical mechanism of antimicrobial host defense. Macrophages recruited to the site of infection are at the crux of this process, employing multiple intersecting mechanisms to orchestrate iron sequestration from pathogens. To gain an integrated understanding of how this is achieved in invasive aspergillosis, we gener...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 427726b9-8bab-5d3f-a820-57f653f954ae
DOI: 10.1101/2022.01.24.477648

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational modeling of macrophage iron sequestration during host defense against <i>Aspergillus</i>DOI 10.1101/2022.01.24.477648Read

Integrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during <i>Aspergillus fumigatus</i> infectionSemantic proximity Read

Myeloid Cell States in Influenza-Associated Pulmonary Aspergillosis Are Shaped by Iron Overload and Metabolic ReprogrammingSemantic proximity Read

A network-based model of <i>Aspergillus fumigatus</i> elucidates regulators of development and defensive natural products of an opportunistic pathogenSemantic proximity Read

Spatiotemporal Analysis of Lung Immune Dynamics in Lethal <i>Coccidioides posadasii</i> InfectionSemantic proximity Read

Iron acquisition and oxidative stress response in aspergillus fumigatus.Semantic proximity Read

Enemy of the (immunosuppressed) state: an update on the pathogenesis of <i>Aspergillus fumigatus</i> infectionSemantic proximity Read

Broad remodeling of the pulmonary immune landscape occurs during IAPA with specific functional deficits of neutrophil subsetsSemantic proximity Read

Heterogeneity in the transcriptional response of the human pathogen <i>Aspergillus fumigatus</i> to the antifungal agent caspofunginSemantic proximity Read

Temporal transcriptional response of <i>Candida glabrata</i> during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and drug resistanceSemantic proximity Read

Differential activation of NF-κB and HIF-1α between alveolar-like macrophages and myeloid-derived macrophages drive inflammatory differences following <i>Mycobacterium abscessus</i> infectionSemantic proximity Read

COVID-19-associated pulmonary aspergillosis in immunocompetent patients: A virtual patient cohort studySemantic proximity Read

Exploring <i>Leishmania</i> -Host Interaction with Reactome, a Database of Biological Pathways and ProcessesSemantic proximity Read