Article
Pharmacogenetics of thiazolidinedione therapy.
Pharmacogenomics - 1 Aug 2007
Aquilante Christina L
Abstract excerpt
The thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor-gamma agonists and have glucose-lowering, insulin-sensitizing and anti-inflammatory effects. TZDs are approved for the treatment of Type 2 diabetes, and have been studied as a diabetes-prevention strategy. Despite widespread use of TZDs, a large number of patients fail to achieve a substantial reduction in glucose, or an improvement in...
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