Article

Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function

2022-12-11

Abstract excerpt

NF2 (Neurofibromine 2, merlin) is frequently inactivated in cancer, where its NF2 tumor suppressor functionality is tightly coupled to protein conformation. How NF2 conformation is regulated and how NF2 conformation influences tumor suppressor activity is a largely open question. Here we systematically characterized three NF2 conformation-dependent protein interactions utilizing deep mutational scanning interactio...

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Literature Corpus work: b1d5de07-468b-5e3e-b46b-b9bd9d175f2c
DOI: 10.1101/2022.12.11.519953

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Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and functionDOI 10.1101/2022.12.11.519953Read

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