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Article

Effects of Nf2 missense mutations on schwannomin interactions.

Biochemical and biophysical research communications - 11 Jan 2002

Scoles Daniel R, Chen Mercy, Pulst Stefan-M

Abstract excerpt

Most benign brain tumors are associated with loss of the Nf2 gene tumor suppressor product schwannomin/merlin. Interactions between schwannomin fragments have given rise to hypotheses of in vivo schwannomin folding and dimerization. Previously, we showed that schwannomin with missense mutations L360P, L535P, and Q538P alters interaction with betaII-spectrin and Hrs. Using yeast two-hybrid tests of interaction, we...

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Identifiers

PMID: 11779178
DOI: 10.1006/bbrc.2001.6178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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