Article

PFOS aggravates atherosclerosis via <i>Bacteroides caecimuris</i> expansion-driven bile acid remodeling and subsequent intestinal FXR–TLR3 signaling cascade

2026-07-08

Abstract excerpt

<h4>BACKGROUND</h4> Perfluorooctane sulfonate (PFOS) is a widely distributed persistent organic pollutant in the environment and has been associated with an increased risk of atherosclerosis. However, the underlying pathogenic mechanisms remain largely unclear. This study aimed to investigate the effects of PFOS on atherosclerosis and its associated gut–vascular axis. <h4>METHODS</h4> Pseudo–germ-free mouse mode...

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Literature Corpus work: 5339a685-5290-5496-bc51-ccfda30797fc
DOI: 10.64898/2026.07.01.735947

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PFOS aggravates atherosclerosis via <i>Bacteroides caecimuris</i> expansion-driven bile acid remodeling and subsequent intestinal FXR–TLR3 signaling cascadeDOI 10.64898/2026.07.01.735947Read

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