Article

Discovery of a unique pathway for glutathione utilization in Francisella

2023-02-02

Abstract excerpt

Glutathione (GSH) is an abundant metabolite that can act as a signal, a nutrient source, or serve in a redox capacity for intracellular pathogens. For Francisella, GSH is thought to be a critical in vivo source of cysteine; however, the cellular pathways permitting GSH utilization by Francisella differ between strains and have remained poorly understood. Using genetic screening, we discovered a unique pathway for...

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Literature Corpus work: b12cb144-012a-5a05-97df-26ad1843bb24
DOI: 10.1101/2023.02.02.526638

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