Article

Ancestral Haplotype Reconstruction in Endogamous Populations using Identity-By-Descent

2020-01-16

Abstract excerpt

In this work we develop a novel algorithm for reconstructing the genomes of ancestral individuals, given genotype or sequence data from contemporary individuals and an extended pedigree of family relationships. A pedigree with complete genomes for every individual enables the study of allele frequency dynamics and haplotype diversity across generations, including deviations from neutrality such as transmission dis...

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Literature Corpus work: b11609b0-cc54-59f1-9f0b-eaca79f552ea
DOI: 10.1101/2020.01.15.908459

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