Article

The histone demethylase KDM5 has insulator activity in the brain

2024-12-04

Abstract excerpt

KDM5 family proteins are best known for their demethylation of the promoter proximal chromatin mark H3K4me3. KDM5-regulated transcription is critical in the brain, with variants in the X-linked paralog KDM5C causing the intellectual disability (ID) disorder Claes-Jensen syndrome. Although the demethylase activity of KDM5C is known to be important for neuronal function, the contribution of non-enzymatic activities...

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Literature Corpus work: b0bd776e-6e26-5d1f-9d1b-31e7e65151a5
DOI: 10.1101/2024.12.04.626780

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