Article
Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability.
American journal of human genetics - 13 Jul 2012
Kleefstra Tjitske, Kramer Jamie M, Neveling Kornelia, Willemsen Marjolein H, Koemans Tom S, Vissers Lisenka E L M, Wissink-Lindhout Willemijn, Fenckova Michaela, van den Akker Willem M R, Kasri Nael Nadif, Nillesen Willy M, Prescott Trine, Clark Robin D, Devriendt Koenraad, van Reeuwijk Jeroen, de Brouwer Arjan P M, Gilissen Christian, Zhou Huiqing, Brunner Han G, Veltman Joris A, Schenck Annette, van Bokhoven Hans
Abstract excerpt
Intellectual disability (ID) disorders are genetically and phenotypically highly heterogeneous and present a major challenge in clinical genetics and medicine. Although many genes involved in ID have been identified, the etiology is unknown in most affected individuals. Moreover, the function of most genes associated with ID remains poorly characterized. Evidence is accumulating that the control of gene...
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