Article
Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C.
BMC medical genomics - 28 Jan 2013
Grafodatskaya Daria, Chung Barian H Y, Butcher Darci T, Turinsky Andrei L, Goodman Sarah J, Choufani Sana, Chen Yi-An, Lou Youliang, Zhao Chunhua, Rajendram Rageen, Abidi Fatima E, Skinner Cindy, Stavropoulos James, Bondy Carolyn A, Hamilton Jill, Wodak Shoshana, Scherer Stephen W, Schwartz Charles E, Weksberg Rosanna
Abstract excerpt
BACKGROUND: A number of neurodevelopmental syndromes are caused by mutations in genes encoding proteins that normally function in epigenetic regulation. Identification of epigenetic alterations occurring in these disorders could shed light on molecular pathways relevant to neurodevelopment. RESULTS: Using a genome-wide approach, we identified genes with significant loss of DNA methylation in blood of males with...
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