Article
A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5.
Cell reports - 27 Feb 2018
Zamurrad Sumaira, Hatch Hayden A M, Drelon Coralie, Belalcazar Helen M, Secombe Julie
Abstract excerpt
Mutations in KDM5 family histone demethylases cause intellectual disability in humans. However, the molecular mechanisms linking KDM5-regulated transcription and cognition remain unknown. Here, we establish Drosophila as a model to understand this connection by generating a fly strain harboring an allele analogous to a disease-causing missense mutation in human KDM5C (kdm5A512P). Transcriptome analysis of...
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