Article

Transcriptional silencing of <i>ALDH2</i> in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

2020-10-23

Abstract excerpt

Hundreds of genes become aberrantly silenced in acute myeloid leukemia (AML), with most of these epigenetic changes being of unknown functional consequence. Here, we demonstrate how gene silencing can lead to an acquired dependency on the DNA repair machinery in AML. We make this observation by profiling the essentiality of the ubiquitin conjugation and ligation machinery in cancer cell lines using domain-focused...

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Literature Corpus work: b0b71923-f837-52f5-9a19-db593a49c536
DOI: 10.1101/2020.10.23.352070

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Transcriptional silencing of <i>ALDH2</i> in acute myeloid leukemia confers a dependency on Fanconi anemia proteinsDOI 10.1101/2020.10.23.352070Read

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