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Reference-Based Versus Reference-Free Cell Type Estimation In DNA Methylation Studies Using Human Placental Tissue

2021-09-09

Abstract excerpt

<title>Abstract</title> <p>The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease risk. However, DNAm studies can be biased by cell type heterogeneity, so it is essential to control for this in order to reduce confounding and increase precision. Compu...

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Literature Corpus work: b0aac965-423a-5a04-a447-0bdb65436513
DOI: 10.21203/rs.3.rs-848651/v1

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