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Article

Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies

1 Feb 2022

Abstract excerpt

The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease risk. However, DNAm studies can be biased by cell type heterogeneity, so it is essential to control for this in order to reduce confounding and increase precision. Computational cell type...

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PMID: 35113241
DOI: 10.1007/s00018-021-04091-3

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