Article

Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties

2025-03-25

Abstract excerpt

To study systemic human innate and adaptive immune responses in detail, competent in vitro lymph node (LN) models with LN stromal cells (LNSCs) are required to recapitulate the physiological microenvironment. The multicellular organisation of LNs possesses a challenge for designing such microphysiological systems (MPS), particularly with the structural complexity of LNs and the lymphatic vasculature. Here, we est...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b099cb0c-4c09-5713-a294-e83ae202a8fb
DOI: 10.1101/2025.03.20.644364

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune propertiesDOI 10.1101/2025.03.20.644364Read

A 3D-printed multi-compartment organ-on-chip platform with a tubing-free pump models communication with the lymph nodeSemantic proximity Read

Microvasculature-on-a-Chip: Bridging the interstitial blood-lymph interface via mechanobiological stimuliSemantic proximity Read

Synthetic cell-based tissues for bottom-up assembly of artificial lymphatic organsSemantic proximity Read

Lymphangiogenesis: <i>in vitro</i> and <i>in vivo</i> modelsSemantic proximity Read

Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targetsSemantic proximity Read

Single-Cell RNA Sequencing Reveals Heterogeneity and Functional Diversity of Lymphatic Endothelial CellsSemantic proximity Read

A robust in vitro model for trans-lymphatic endothelial migration.Semantic proximity Read

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodesSemantic proximity Read

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunitySemantic proximity Read

Enhancing Patient Lymphocyte Response to Peritoneal Malignancies Using a Personalized Immunocompetent Microfluidic Co-Culture PlatformSemantic proximity Read

A versatile microfluidic extrusion-based hydrogel platform for self-organization and long-term maintenance of engineered 3D lymphatic endotheliumSemantic proximity Read

Lymphoid-tissue-on-chip recapitulates human antibody responses in vitroSemantic proximity Read