Article

p62 sorts Lupus La and selected microRNAs into breast cancer-derived exosomes

2025-03-20

Abstract excerpt

Exosomes are multivesicular body-derived extracellular vesicles that are secreted by metazoan cells. Exosomes have utility as disease biomarkers, and exosome-mediated miRNA secretion has been proposed to facilitate tumor growth and metastasis. Previously, we demonstrated that the Lupus La protein (La) mediates the selective incorporation of miR-122 into metastatic breast cancer-derived exosomes; however, the mecha...

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Literature Corpus work: b0656c22-a7d6-51e8-8790-aa4bcdf8aa54
DOI: 10.1101/2025.03.20.644464

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