Article
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.
Nature communications - 1 Jan 2013
Villarroya-Beltri Carolina, Gutiérrez-Vázquez Cristina, Sánchez-Cabo Fátima, Pérez-Hernández Daniel, Vázquez Jesús, Martin-Cofreces Noa, Martinez-Herrera Dannys Jorge, Pascual-Montano Alberto, Mittelbrunn María, Sánchez-Madrid Francisco
Abstract excerpt
Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to recipient cells. However, the mechanisms that control the specific loading of RNA species into exosomes remain unknown. Here we describe sequence motifs present in...
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