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An Alternatively Spliced p62 Isoform Confers Resistance to Chemotherapy in Breast Cancer

29 Aug 2022

Abstract excerpt

Resistance to chemotherapy remains a major obstacle to the successful treatment of breast cancer. More than 80% of patients who receive neoadjuvant chemotherapy (NAC) do not achieve a pathologic complete response. In this study, we report a novel p62 mRNA isoform with a short 3'-UTR (untranslated region; p62-SU, 662-nt) that is associated with chemoresistance in breast cancer cells and tissue specimens. The p62...

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PMID: 36041072
DOI: 10.1158/0008-5472.can-22-0909

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