Enalapril mitigates senescence and aging-related phenotypes by targeting antioxidative genes via phosphorylated Smad1/5/9

Abstract excerpt

<h4>ABSTRACT</h4> Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study, we revealed that enalapril, a drug widely prescribed for hypertension, can improve both cellular senescence and individual health. Mechanistica...

Topics

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• Apelin-related biomedical research
• Genetics, Aging, and Longevity in Model Organisms
• Hormonal Regulation and Hypertension
• Liver Disease Diagnosis and Treatment
• Nitric Oxide and Endothelin Effects
• Renin-Angiotensin System Studies
• Sirtuins and Resveratrol in Medicine
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

9e45b1b8-c083-5a94-8c72-4e06e91d9b15

DOI

10.1101/2024.11.27.625711