Article
Identification of candidate genes in scleroderma-related pulmonary arterial hypertension.
Translational research : the journal of laboratory and clinical medicine - 1 Apr 2008
Grigoryev Dmitry N, Mathai Stephen C, Fisher Micah R, Girgis Reda E, Zaiman Ari L, Housten-Harris Traci, Cheadle Christopher, Gao Li, Hummers Laura K, Champion Hunter C, Garcia Joe G N, Wigley Fredrick M, Tuder Rubin M, Barnes Kathleen C, Hassoun Paul M
Abstract excerpt
We hypothesize that pulmonary arterial hypertension (PAH)-associated genes identified by expression profiling of peripheral blood mononuclear cells (PBMCs) from patients with idiopathic pulmonary arterial hypertension (IPAH) can also be identified in PBMCs from scleroderma patients with PAH (PAH-SSc). Gene expression profiles of PBMCs collected from IPAH (n = 9), PAH-SSc (n = 10) patients, and healthy controls (n...
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