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Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome

18 Dec 2018

Abstract excerpt

Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary artery pressure and vascular resistance, typically leading to right heart failure and death. Current therapies improve quality of life of the patients but have a modest effect on long-term survival. A detailed transcriptomics and systems biology view of the PAH lung is expected to provide new testable hypotheses for exploring novel...

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PMID: 30562042
DOI: 10.1165/rcmb.2018-0368oc

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