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Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1

22 Feb 2023

Abstract excerpt

COVID-19 lung pathology is characterized by interstitial pneumonia with cell-cell fusion-induced syncytia and extensive tissue damage. 1 The correlation between viral fusogenicity and pathogenicity has been reported in SARS-CoV-2 variants. 2 Compared with the previous Delta or D614G variants, Omicron BA.1 has been proven to be less fusogenic and pathogenic, 3 potentially due to the high burden of mutations in...

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PMID: 36810728
DOI: 10.1038/s41392-022-01281-8

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