Article

Using selective lung injury to improve murine models of spatially heterogeneous lung diseases

2018-08-06

Abstract excerpt

Many lung diseases, such as acute respiratory distress syndrome (ARDS), display significant regional heterogeneity, with patches of severely injured tissue adjacent to apparently healthy tissue. Current mouse models that aim to mimic ARDS generally produce diffuse injuries that cannot reproducibly generate ARDS’s regional heterogeneity. This deficiency prevents the evaluation of how well therapeutic agents reach t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b03b5308-0463-5994-8cd3-64ede15cd7b7
DOI: 10.1101/385922

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using selective lung injury to improve murine models of spatially heterogeneous lung diseasesDOI 10.1101/385922Read

Lung repair and regeneration: Advanced models and insights into human diseaseSemantic proximity Read

Murine models of pulmonary fibrosis: mechanisms, limitations and translational insights.Semantic proximity Read

Use of precision cut lung slices as a translational model for the study of lung biologySemantic proximity Read

In Vitro Modeling of Idiopathic Pulmonary Fibrosis: Lung-on-a-Chip Systems and Other 3D CulturesSemantic proximity Read

Understanding alveolarization to induce lung regenerationSemantic proximity Read

Lung derived extracellular vesicles have distinct pro-repair effects, depending on the age of their source tissueSemantic proximity Read

Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injurySemantic proximity Read

Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposuresSemantic proximity Read

Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 componentsSemantic proximity Read

Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair.Semantic proximity Read

Novel Apelin-expressing gCap Endothelial Stem-like Cells Orchestrate Lung Microvascular RepairSemantic proximity Read

Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directionsSemantic proximity Read