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Article

A2AR-mediated inhibition of B cell maturation: a novel mechanism of immune suppression in cancer

2025-08-16

Abstract excerpt

High levels of extracellular adenosine, highly abundant in the tumor microenvironment, promote immune suppression mainly through the A2AR expressed by tumor-infiltrating immune cells. Here we show that plasma cells are the most negatively affected by adenosine among the immune cells present in the tumor microenvironment. Furthermore, both tonsillar and tumor-associated B cells, including germinal center (GC)-like...

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Literature Corpus work
b00b62df-d78c-56a2-9fa9-900e1de631f1
DOI
10.1101/2025.08.13.669666
Open publication

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