Article

mtDNA diversity in human populations highlights the merit of haplotype matching in gene therapies

2016-08-30

Abstract excerpt

Modern gene therapies aim to prevent the inheritance of mutant mitochondrial DNA (mtDNA) from mother to offspring by using a third-party mtDNA background. Technological limitations mean that these therapies may result in a small amount of maternal mtDNA admixed with a majority of third-party mtDNA. This situation is unstable if the mother’s mtDNA experiences a proliferative advantage over the third-party mtDNA, in...

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Literature Corpus work: aff58d28-7190-5a74-ba6c-becb817d86c6
DOI: 10.1101/072348

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