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Article

Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.

Proteins - 1 Sept 2017

Sayyed-Ahmad Abdallah, Prakash Priyanka, Gorfe Alemayehu A

Abstract excerpt

Despite years of study, the structural or dynamical basis for the differential reactivity and oncogenicity of Ras isoforms and mutants remains unclear. In this study, we investigated the effects of amino acid variations on the structure and dynamics of wild type and oncogenic mutants G12D, G12V, and G13D of H- and K-Ras proteins. Based on data from µs-scale molecular dynamics simulations, we show that the overall...

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Identifiers

PMID: 28498561
DOI: 10.1002/prot.25317
PMCID: PMC5568977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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