Article

Detection of HPV E7 transcription at single-cell resolution in epidermis

2018-01-24

Abstract excerpt

<h4>Summary</h4> Persistent human papillomavirus (HPV) infection is responsible for at least 5% of human malignancies. Most HPV-associated cancers are initiated by the HPV16 genotype, as confirmed by detection of integrated HPV DNA in cells of oral and anogenital epithelial cancers. However, single-cell RNA-sequencing (scRNA-seq) may enable prediction of HPV involvement in carcinogenesis at other sites. We conduc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: afcedb02-cd01-51d1-a522-cbf2c7c3b942
DOI: 10.1101/252858

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detection of HPV E7 transcription at single-cell resolution in epidermisDOI 10.1101/252858Read

Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancerSemantic proximity Read

Digital RNA Sequencing of Human Epidermal Keratinocytes Carrying Human Papillomavirus Type 16 E7Semantic proximity Read

Full-length single-cell RNA-seq applied to a viral human cancer: applications to HPV expression and splicing analysis in HeLa S3 cellsSemantic proximity Read

Modulation of microRNA-mRNA Target Pairs by Human Papillomavirus 16 OncoproteinsSemantic proximity Read

MmuPV1 E7 promotes phenotypes associated with "high-risk" HPV infection in mouse keratinocytes.Semantic proximity Read

Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse modelSemantic proximity Read

The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissuesSemantic proximity Read

Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice.Semantic proximity Read

The mouse papillomavirus epigenetic signature is characterised by DNA hypermethylation after lesion regressionSemantic proximity Read

A tumor necrosis factor-α responsive cryptic promoter drives overexpression of the human endogenous retrovirus <i>ERVK-7</i>Semantic proximity Read

HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell ExpansionSemantic proximity Read

The Mus musculus papillomavirus type 1 E7 protein binds to the retinoblastoma tumor suppressor - implications for viral pathogenesisSemantic proximity Read