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Article

MmuPV1 E7 promotes phenotypes associated with "high-risk" HPV infection in mouse keratinocytes.

Journal of virology - 25 Nov 2025

Duxbury Kayla R, Zhang Liyan, Muelhbauer Laura K, Hayes Mitchell, Coon Joshua J, Padi Megha, Romero-Masters James C

Abstract excerpt

The E7 oncoprotein of mouse papillomavirus (MmuPV1) plays a pivotal role in both viral infection and cancer development. While earlier studies have identified key cellular targets of MmuPV1 E7, such as pRB and PTPN14, the broader impact of MmuPV1 E7 on keratinocyte homeostasis and shared activities with human papillomavirus (HPV) E7 remains unclear. In this study, we employed proteomic and transcriptomic analyses...

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Share to Human papillomavirus 16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Viral

Share to Papillomavirus E7 Proteins

Share to Papillomavirus Infections

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 41165329
DOI: 10.1128/jvi.01097-25
PMCID: PMC12645909

Genes

PTPN14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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