Article

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

2020-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Mutation-driven evolution of SARS coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously suppress viral replication and circumvent viral escape routes from host immunity and antiviral therapeutics. Here, we employed genome-wide computational prediction and singlenucleotide resolution screening to reprogram CRISPR-Cas13b against SARS-CoV-2 genomic and subgeno...

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Literature Corpus work: afccbb00-2104-512f-8774-3b5f35c54607
DOI: 10.1101/2020.11.18.389312

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