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Article

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance.

Nature communications - 13 Jul 2021

Fareh Mohamed, Zhao Wei, Hu Wenxin, Casan Joshua M L, Kumar Amit, Symons Jori, Zerbato Jennifer M, Fong Danielle, Voskoboinik Ilia, Ekert Paul G, Rudraraju Rajeev, Purcell Damian F J, Lewin Sharon R, Trapani Joseph A

Abstract excerpt

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously suppress viral replication and circumvent viral escape from host immunity and antiviral therapeutics. Here, we employ genome-wide computational prediction and single-nucleotide resolution screening to reprogram CRISPR-Cas13b against SARS-CoV-2 genomic and...

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Identifiers

PMID: 34257311
DOI: 10.1038/s41467-021-24577-9
PMCID: PMC8277810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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