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Programmable Inhibition and Detection of RNA Viruses Using Cas13

10 Oct 2019

Abstract excerpt

The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA) viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA). Here, we computationally identify thousands of potential Cas13 crRNA target sites in hundreds of ssRNA viral species that can potentially infect humans. We experimentally demonstrate Cas13's potent activity against three distinct ssRNA...

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PMID: 31607545
DOI: 10.1016/j.molcel.2019.09.013

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