Back to search

Article

Cambodian<i>Plasmodium vivax</i>parasites with reduced hemoglobin digestion display delayed clearance upon artesunate treatment

2025-03-11

Abstract excerpt

<h4>Summary</h4> Artemisinin-based combination therapies are the frontline drugs for the treatment of malaria infections but, for Plasmodium falciparum, the efficacy of artemisinin is threatened by the spread of resistance . P. vivax is the second most common cause of human malaria but we have little information on its susceptibility to artemisinin due to the lack of in vitro cultures. Here, we analyze 161 P. viva...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
87de6e75-54b2-5672-b200-b3310ad5b42c
DOI
10.1101/2025.03.09.25323469
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cambodian<i>Plasmodium vivax</i>parasites with reduced hemoglobin digestion display delayed clearance upon artesunate treatmentDOI 10.1101/2025.03.09.25323469
Challenges in Plasmodium diagnostics in countries nearing malaria elimination: a cross-sectional survey among treatment-seeking patients in health facilities in malaria endemic provinces of Cambodia with contrasted transmission intensitySemantic proximity
Temporal trends in <i>Plasmodium vivax</i> diversity in eastern Cambodia evidence declining transmissionSemantic proximity
Delayed parasite clearance after treatment with dihydroartemisinin-piperaquine in Plasmodium falciparum malaria patients in central Vietnam.Semantic proximity
<i>In vivo</i> delayed clearance of <i>Plasmodium falciparum</i> malaria independent of <i>kelch13</i> polymorphisms and with escalating malaria in BangladeshSemantic proximity
Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study.Semantic proximity
Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparumSemantic proximity
Single-cell RNA profiling of <i>Plasmodium vivax</i> -infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targetsSemantic proximity
Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoformsSemantic proximity
Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in CambodiaSemantic proximity
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.Semantic proximity
<i>In vivo</i> gene expression analyses provide unique insights on <i>P. vivax</i> gametocytogenesis and chloroquine responseSemantic proximity
A common DNA deletion altering the 3’UTR of mdr1 is associated with reduced mefloquine susceptibility in P. vivax parasites from Cambodian patientsSemantic proximity
Select a neighboring publication to make it the new centre.