Article

Selective Expression of Variant Surface Antigens Enables <i>Plasmodium falciparum</i> to Evade Immune Clearance <i>in vivo</i>

2020-07-22

Abstract excerpt

Plasmodium falciparum has developed extensive mechanisms to evade host immune clearance. Currently, most of our understanding is based on in vitro studies of individual parasite variant surface antigens and how this relates to the processes in vivo is not well-understood. Here, we have used a humanized mouse model to identify parasite factors important for in vivo growth. We show that upregulation of the specif...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06ccb73b-f618-586d-81bb-30c2c7225829
DOI: 10.1101/2020.07.22.215640

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective Expression of Variant Surface Antigens Enables <i>Plasmodium falciparum</i> to Evade Immune Clearance <i>in vivo</i>DOI 10.1101/2020.07.22.215640Read

Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivoSemantic proximity Read

Antigenic Variation in <i>Plasmodium falciparum</i> : Gene Organization and Regulation of the <i>var</i> Multigene FamilySemantic proximity Read

Variable surface antigen expression, virulence, and persistent infection by Plasmodium falciparum malaria parasitesSemantic proximity Read

A system for functional studies of the major virulence factor of malaria parasitesSemantic proximity Read

Antigenic Variation in<i>Plasmodium falciparum</i>Semantic proximity Read

Variant Gene Expression and Antigenic Variation by Malaria ParasitesSemantic proximity Read

<i>Plasmodium falciparum</i> Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A <i>var</i> GenesSemantic proximity Read

A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies.Semantic proximity Read

The delayed bloodstream clearance of <i>Plasmodium falciparum</i> parasites after M5717 treatment is attributable to the inability to modify their red blood cell hostsSemantic proximity Read

<i>Plasmodium</i> P25 and P28 Surface Proteins: Potential Transmission-Blocking VaccinesSemantic proximity Read

Variant antigen gene expression in malariaSemantic proximity Read

Reversible host cell surface remodelling limits immune recognition and maximizes transmission of <i>Plasmodium falciparum</i> gametocytesSemantic proximity Read