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TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma

30 May 2025

Abstract excerpt

PURPOSE: Telomerase reverse transcriptase (TERT) is one of the most well-established oncogenes in tumor development and progression. It is widely known that TERT promoter hypermethylation is associated with its transcription activation. Despite its canonical role in maintaining telomere length in cancer cells, TERT is also involved in various oncogenic processes independent of its enzymatic activity. However, the...

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Share to Epigenetics and DNA Methylation
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PMID: 40448175
DOI: 10.1186/s13148-025-01897-x

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