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Article

Patterns of ribosomal protein expression specify normal and malignant human cells

24 Nov 2016

Abstract excerpt

BACKGROUND: Ribosomes are highly conserved molecular machines whose core composition has traditionally been regarded as invariant. However, recent studies have reported intriguing differences in the expression of some ribosomal proteins (RPs) across tissues and highly specific effects on the translation of individual mRNAs. RESULTS: To determine whether RPs are more generally linked to cell identity, we analyze...

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PMID: 27884178
DOI: 10.1186/s13059-016-1104-z

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