Article

Molecular anatomy of eosinophil activation by IL5 and IL33

2022-12-21

Abstract excerpt

<h4>ABSTRACT</h4> IL5 and IL33 are major activating cytokines that cause circulating eosinophils to polarize, adhere, and release their granule contents. We correlated microscopic features of purified human blood eosinophils stimulated for 10 min with IL5 or IL33 with phosphoproteomic changes determined by multiplexed isobaric labeling. IL5 caused phosphorylation of sites implicated in JAK/STAT signaling and loca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af3ded24-c740-5af5-98e9-a2bec826c2f6
DOI: 10.1101/2022.12.21.521419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular anatomy of eosinophil activation by IL5 and IL33DOI 10.1101/2022.12.21.521419Read

Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplificationSemantic proximity Read

Eosinophils: Biological Properties and Role in Health and DiseaseSemantic proximity Read

Flow Cytometric Methods for the Detection of Intracellular Signaling Proteins and Transcription Factors Reveal Heterogeneity in Differentiating Human B Cell SubsetsSemantic proximity Read

Transcription Factor Repertoire of Homeostatic EosinophilopoiesisSemantic proximity Read

Spatial Eosinophil Phenotypes as Immunopathogenic Determinants in Inflammatory DiseasesSemantic proximity Read

GAPDH nuclear signaling regulates neutrophil migration and inflammatory skin responsesSemantic proximity Read

Transcription factor and cytokine regulation of eosinophil lineage commitmentSemantic proximity Read

Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells.Semantic proximity Read

Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cellsSemantic proximity Read

Phostensin Enables Lymphocyte Integrin Activation and Population of Peripheral Lymphoid OrgansSemantic proximity Read

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene lociSemantic proximity Read

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.Semantic proximity Read