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Article

Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand

26 May 2025

Abstract excerpt

Poly(ADP-ribose) polymerase 1 (PARP1) is a multifunctional protein involved in diverse cellular functions, notably DNA damage repair. Pharmacological inhibition of PARP1 has therapeutic benefits for various pathologies. Despite the increased use of PARP inhibitors, challenges persist in achieving PARP1 selectivity and effective blood–brain barrier (BBB) penetration. The development of a PARP1-specific positron...

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PMID: 41132858
DOI: 10.1016/j.apsb.2025.05.020

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