Article

A novel <sup>18</sup> F-labeled brain penetrant PET ligand for imaging poly(ADP-ribose) polymerase-1

2025-11-03

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) is a key mediator of DNA repair, and its inhibition has become a validated therapeutic strategy in homologous recombination–deficient cancers. However, tools for non-invasive assessment of PARP-1-specific expression remain limited. Here, we evaluated [ 18 F]AZD9574, a next-generation PARP-1-selective PET radiotracer. [ 18 F]AZD9574 was tested in a panel of breast, glioblast...

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Literature Corpus work: be4ca9f4-f7a4-5a1e-b10f-e2073ce525f1
DOI: 10.1101/2025.11.01.686021

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