Article

Determination of Slow-binding HDAC Inhibitor Potency and Subclass Selectivity

2021-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Histone deacetylases (HDACs) 1–3 regulate chromatin structure and gene expression. These three enzymes are targets for cancer chemotherapy and are studied for the treatment of immune disorders and neurodegeneration, but there is a lack of selective pharmacological tool compounds to unravel their individual roles. Potent inhibitors of HDACs 1–3 often display slow-binding kinetics, which causes a...

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Literature Corpus work: 306fbb4c-0c91-577d-8c26-1116b4ca6cf7
DOI: 10.1101/2021.12.18.473277

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